At a glance
| Chemical family | BPA & Bisphenols |
| CAS number | 1478-61-1 |
| IARC classification | Not classified |
| Activated carbon capture | Limited |
| Evidence strength | Limited |
| Primary audience | General population, parents |
Regulatory & certification status
Where BPAF (Bisphenol AF) stands across the major regulatory systems and the certifications a bedroom product might carry. Each row links to the governing instrument; where a jurisdiction has no specific measure, that is stated plainly rather than left blank.
| European Union | REACH Substance of Very High Concern: added to the Candidate List on 4 February 2026 (bringing the list to 253 entries) as "4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and its salts" (Bisphenol AF; EC 216-036-7) for being toxic for reproduction (Art. 57(c)). It carries a harmonised CLP classification as a reproductive toxicant Category 1B (H360Fd), adopted via the 21st ATP to CLP (Commission Delegated Regulation (EU) 2024/197) and applying from 1 September 2025. As a bisphenol with a harmonised CMR 1B classification it is named among the hazardous bisphenols captured by the ban on bisphenols in food-contact materials (Commission Regulation (EU) 2024/3190). It is not on the Authorisation List (Annex XIV) and is not on the Annex XVII restriction list as a discrete entry. Regulatory — EUR-Lex · ECHA |
| United States | No TSCA risk evaluation or regulatory action specific to BPAF has been identified; the NTP has conducted developmental/reproductive toxicity research on Bisphenol AF, but that is a research report, not a regulation. Under California Proposition 65, BPAF is NOT currently listed. On 21 October 2025 OEHHA selected the class of p,p'-bisphenol chemicals (which includes BPAF) for the DARTIC's review for possible reproductive-toxicity listing, opening a data call-in — a proposed/draft step only, not a final listing. (Bisphenol S, a separate member of that family, has been added to the Prop 65 list; BPAF has not.) Regulatory — OEHHA |
| Canada | No final CEPA Schedule 1 listing specific to BPAF has been identified. BPAF falls within the group of BPA structural analogues and functional alternatives (BPA SAFAs) being addressed under the Chemicals Management Plan: a November 2021 CEPA s.71 information-gathering notice (Canada Gazette, 13 Nov 2021) applied to 188 such substances. This is an information-gathering / assessment stage, not a finalized risk-management instrument for BPAF. Regulatory — Canada Gazette · Government of Canada |
| Australia | No specific AICIS / IMAP (or legacy NICNAS) assessment or restriction identified for Bisphenol AF (CAS 1478-61-1) as a discrete substance; related bisphenol-based polymers have been assessed but not BPAF itself. Regulatory — AICIS |
| United Kingdom | BPAF is NOT on the UK REACH Candidate List; post-Brexit, EU Candidate List additions (BPAF was added in the EU on 4 Feb 2026) do not carry over automatically and require a separate HSE/GB process. HSE has signalled interest in how bisphenols including BPAF are manufactured/used in GB, but legal adoption of a GB Mandatory Classification and Labelling entry for BPAF could not be confirmed from a primary source. Regulatory — HSE |
| Certifications | CertiPUR-US: not addressed by name — its prohibited-substance list targets certain flame retardants (e.g. TCEP, TDCPP), CPSC-regulated phthalates, formaldehyde and total VOCs in foam, and screens for substances classified CMR under GHS, but does not name BPAF. OEKO-TEX Standard 100: restricts Bisphenol A (limit lowered from 100 to 10 mg/kg for 2025) but does not name Bisphenol AF as a separate regulated parameter. GREENGUARD / GREENGUARD Gold: a low-VOC emissions certification (UL 2818) that does not screen for a non-volatile bisphenol like this. Industry — CertiPUR-US · OEKO-TEX |
| The 72-hour test window | Largely missed. Bisphenol AF is a non-volatile, higher-molecular-weight SVOC/additive (MW ~336) that migrates into house dust and via contact rather than off-gassing, so a short ~72-hour VOC chamber test does not reliably capture it. Inferred — from the compound's volatility/emission profile versus the VOC focus of short chamber tests |
What it is
BPAF — bisphenol AF, CAS 1478-61-1 — is a fluorinated analog of bisphenol A. The two -CF₃ groups in place of BPA's methyl groups increase thermal stability and alter biological activity. It is used in specialty polymers, fluoroelastomers, and high-performance coatings as a BPA replacement.
Where you encounter it
BPAF's bedroom exposure pathways are less well-characterized than other bisphenols. It appears in some elastomers, fluoropolymer coatings, and specialty adhesives. Its presence in mass-market bedding and mattresses is comparatively limited, though public biomonitoring data remains sparse.
Why it matters for sleep environments
NIH National Toxicology Program studies have documented estrogen-receptor binding activity that is in some assays higher than BPA itself. Peer-reviewed — NTP 2009 report on BPAF BPAF is included in the Atlas to complete coverage of the bisphenol family and to support the position that "BPA-free" claims require nuance — the replacement chemistry matters.
Related compounds
This is a preview of an Atlas entry under development. Last reviewed 2026-05-19. If you find a factual error, contact us.