At a glance
| Chemical family | A synthetic preservative (isothiazolinone biocide); a potent skin sensitiser |
| CAS number | 2682-20-4 |
| Classification | Not a carcinogen or systemic toxicant — the concern is allergy. A leading cause of allergic contact dermatitis; American Contact Dermatitis Society Allergen of the Year 2013 |
| Where you encounter it | Rinse-off cosmetics (shampoos, washes), wet wipes; and non-cosmetic products including water-based wall paints, glues and cleaning agents |
| Sleep micro-environment relevance | A personal-care residue on skin and bedding — and, distinctively, an airborne allergen released by freshly painted bedroom walls |
| Activated carbon capture | Not the main lever — product choice (MIT-free cosmetics; low-biocide paint) and ventilation while paint cures matter most |
Regulatory & certification status
Where Methylisothiazolinone stands across the major regulatory systems and the certifications a bedroom product might carry. Each row links to the governing instrument; where a jurisdiction has no specific measure, that is stated plainly rather than left blank.
| European Union | Harmonised CLP classification (Regulation 1272/2008 Annex VI, index 613-326-00-9, inserted by Commission Regulation (EU) 2018/1480, applicable from 1 May 2020): Skin Sens. 1A (H317; specific concentration limit C≥0.0015%), Acute Tox. 2/3, Skin Corr. 1B, Eye Dam. 1, Aquatic Acute 1/Chronic 1 (M=10/1); it does not appear on the REACH SVHC Candidate List or Authorisation List (Annex XIV) as of mid-2026. Separately restricted under the EU Cosmetics Regulation Annex V, via the entry for methylisothiazolinone used alone (entry 57 — distinct from the separate, older 3:1 CMIT/MIT mixture entry, entry 39, which carries its own long-standing rinse-off-only limit): banned from leave-on cosmetic products since 12 Feb 2017 (Reg. (EU) 2016/1198) and capped at 0.0015% (15 ppm) in rinse-off products since 27 Apr 2018, down from a prior 100 ppm limit (Reg. (EU) 2017/1224). Regulatory — EUR-Lex · HSE |
| United States | Not on California's Proposition 65 list (no entry for CAS 2682-20-4 on the current OEHHA list) and not subject to any EPA TSCA risk evaluation or High-Priority Substance designation. Its principal US federal oversight instead sits under FIFRA, not TSCA: EPA issued a Reregistration Eligibility Decision (RED) for methylisothiazolinone as a registered antimicrobial pesticide active ingredient (1998). Regulatory — OEHHA · Federal Register |
| Canada | No listing on CEPA Schedule 1 (List of Toxic Substances): absent from all 348 entries in the Government of Canada's official Schedule 1 substance register, cross-checked directly rather than by keyword search alone. Separately, under the Food and Drugs Act rather than CEPA, Health Canada's Cosmetic Ingredient Hotlist prohibits MIT in leave-on cosmetics and caps rinse-off use at 0.0015% (15 ppm), mirroring the EU limit. Regulatory — Justice Laws Canada · Government of Canada |
| Australia | AICIS (formerly NICNAS) Human Health Tier II/III IMAP assessments concluded methylisothiazolinone is a potent skin sensitiser and recommended GHS-aligned hazard classification and use restrictions. Consistent with that, MIT (together with methylchloroisothiazolinone) has been listed on Schedule 6 of the Poisons Standard since 1 October 2019, capping cosmetic use at 0.0015% (15 ppm) in rinse-off products or 0.1% in other preparations not intended for direct skin contact. A 2022 TGA delegate decision considered an application to further tighten this entry and decided not to amend it, confirming these limits remain current. Regulatory — AICIS · TGA |
| United Kingdom | The UK inherited the EU harmonised classification at the end of the Brexit transition: MIT carries an identical entry on the GB Mandatory Classification and Labelling (GB MCL) list maintained by HSE (index 613-326-00-9) — Skin Sens. 1A (H317; SCL ≥0.0015%), Acute Tox. 2/3, Skin Corr. 1B, Eye Dam. 1, Aquatic Acute 1/Chronic 1. No UK REACH SVHC listing or GB-specific restriction beyond this inherited classification was identified. Regulatory — HSE |
| Certifications | CertiPUR-US: not specifically addressed — MIT is absent from the Technical Guidelines' named prohibited-substances list, and its Skin Sens. 1A classification falls outside CertiPUR-US's automatic GHS-based triggers, which cover only Carcinogen/Germ-cell-mutagen/Reproductive-toxicity Category 1A/1B. OEKO-TEX Standard 100: carries no current numeric limit — MIT was previously on the "under observation" watch-list but was formally removed from it in the April 2025 limit-value update. GREENGUARD/GREENGUARD Gold: a low-VOC emissions certification whose named target-VOC list omits MIT and would not reliably screen for a low-volatility additive like this. Industry — CertiPUR-US · OEKO-TEX |
| The 72-hour test window | Largely missed. MIT is a low-volatility, water-soluble preservative that works by remaining active in the wet formulation rather than off-gassing, and it is not a named target analyte in the CertiPUR-US or GREENGUARD VOC chamber-test panels — a short ~72h emissions test would not reliably capture it; targeted chemical residue analysis of the finished material is the more appropriate detection method. Inferred — from the compound's volatility/emission profile versus the VOC focus of short chamber tests |
What it is
Methylisothiazolinone is a biocide — a preservative that kills the microbes that would otherwise spoil any water-based product. Regulatory — EU Cosmetics Regulation Annex V It rose to prominence in the mid-2000s as a replacement for older preservatives, and was used widely — and, it turned out, at concentrations high enough to sensitise. The result, through the 2010s, was an epidemic of allergic contact dermatitis traced to cosmetics, wipes and paints, severe enough that MIT was named the American Contact Dermatitis Society's Allergen of the Year for 2013. Peer-reviewed — Gonçalo et al. 2013
The key point about its hazard is that it is an allergen, not a poison. It is not classified as a carcinogen, and the worry is not systemic toxicity but sensitisation — the immune system learning to react to it, after which even trace exposures provoke dermatitis. Inferred — distinguishing sensitisation from systemic toxicity That distinction shapes everything about how to think about it.
How it relates to the bedroom
The personal-care route
Like the rest of the personal-care family, MIT reaches the sleep environment through products applied to skin and hair: shampoos, body washes and wet wipes that leave residue on skin and on the bedding it touches. Peer-reviewed — Gonçalo et al. 2013 European regulators acted on exactly this exposure, banning MIT from leave-on cosmetics and capping it in rinse-off products at 15 parts per million — a level judged low enough not to sensitise people who are not already allergic. Regulatory — EU Annex V; SCCS opinions
The paint on the walls — the unusual route
This is what sets MIT apart in a bedroom atlas. It is a preservative in water-based (latex) wall paints, and freshly painted rooms have caused airborne allergic contact dermatitis — reactions to the MIT released into room air as the paint cures, affecting the face and eyelids of sensitized people without their touching anything. Peer-reviewed — Gonçalo et al. 2013 For a room you sleep in for a third of every day, a newly painted wall that keeps off-gassing a known allergen is a genuinely bedroom-specific exposure, and one that ordinary "air out the new mattress" advice would miss entirely. Inferred — extending the documented airborne-paint reactions to the bedroom setting
The honest, proportionate verdict
The calibration matters. For the large majority of people who are not sensitized to MIT, the regulated levels in today's products are low-concern. Regulatory — EU SCCS For the minority who are sensitized — a few percent of dermatology patients at the epidemic's peak — it is a real and sometimes debilitating problem, and the airborne-from-paint route can make a bedroom uncomfortable to occupy. Peer-reviewed — Gonçalo et al. 2013 Encouragingly, the regulation worked: allergy rates roughly halved in Europe after the restrictions, even as they continued rising in North America under looser rules. Peer-reviewed — Reeder et al. 2023
What the research says
- It caused an allergy epidemic. A leading contact allergen; Allergen of the Year 2013. Peer-reviewed — Gonçalo et al. 2013
- It is airborne from fresh paint. Recently painted rooms have triggered airborne allergic dermatitis. Peer-reviewed — Gonçalo et al. 2013
- Regulation reduced the harm. EU banned it in leave-on cosmetics and capped rinse-off at 15 ppm; allergy rates halved in Europe. Regulatory — EU Annex V Peer-reviewed — Reeder et al. 2023
- It is an allergen, not a poison. Not a carcinogen or systemic toxicant; the issue is sensitisation. Inferred
What helps reduce it
Check cosmetic and wipe labels. Look for "methylisothiazolinone" or "methylchloroisothiazolinone"; EU rules now keep it out of leave-on cosmetics and limit it in rinse-off products. Regulatory — EU Annex V
Choose low-biocide or isothiazolinone-free paint for bedrooms. The highest-value bedroom step if you or a family member reacts to fresh paint. Inferred — from the documented paint-airborne reactions
Ventilate well while paint cures. Fresh-air exchange clears the airborne preservative as the paint dries. Inferred
What does NOT help
- Worrying about it as a toxin. MIT is an allergen; if you are not sensitized, regulated levels are low-concern, and the productive focus is on people who react. Regulatory — EU SCCS
- Assuming "the smell is gone" means the allergen is gone. Airborne MIT from paint can persist past the obvious paint smell. Inferred
Open research questions
- How long water-based wall paint continues to release MIT into bedroom air after application, and at what concentrations relative to sensitisation thresholds. Speculation
- Whether the rise of substitute preservatives such as benzisothiazolinone is shifting, rather than solving, the bedroom allergen burden. Speculation
The Embr Exposure Ledger: Methylisothiazolinone
One chemical, several public questions, answered from independent datasets and joined here — the environment it shows up in, the body burden it carries, how it is regulated, and what actually reduces it.
Detection and body-burden figures are occurrence data, not a personal measurement or a health diagnosis. Part of the Embr Exposure Ledger — an open, cross-dataset chemical join (download the data), reusable with attribution.
Citations
- Gonçalo M, et al. (2013). Whilst Rome Burns: The Epidemic of Contact Allergy to Methylisothiazolinone. Contact Dermatitis. MI in paints and cosmetics; airborne dermatitis from recently painted walls; named US Allergen of the Year 2013. Via Consensus. DOI 10.1111/cod.12098 Peer-reviewed
- Reeder MJ, et al. (2023). Trends in the Prevalence of Methylchloroisothiazolinone/Methylisothiazolinone Contact Allergy in North America and Europe. JAMA Dermatology. Peaked in Europe 2013–14, declined after stricter EU regulation; still rising in North America. Via Consensus. DOI 10.1001/jamadermatol.2022.5991 Peer-reviewed
- EU Cosmetics Regulation (EC) No 1223/2009, Annex V — Methylisothiazolinone, with SCCS opinions SCCS/1521/13 and SCCS/1557/15. Banned in leave-on cosmetics; restricted to 15 ppm in rinse-off; also used in paints, glues and cleaning agents. Documented in Cosmetics Europe COSMILE. cosmileeurope.eu Regulatory
Frequently asked questions
What is methylisothiazolinone?
Methylisothiazolinone — MIT or MI — is a synthetic preservative (biocide) used to stop microbes growing in water-based products. It is found in rinse-off cosmetics like shampoos and body washes, in wet wipes, and, importantly for the bedroom, in water-based wall paints, glues and cleaning agents. Its claim to fame is unfortunate: a sharp rise in its use after 2005 triggered an epidemic of allergic skin reactions, and the American Contact Dermatitis Society named it Allergen of the Year for 2013.
Why is it relevant to the bedroom specifically?
Two reasons. First, like other personal-care ingredients, MIT in shampoos, washes and wet wipes leaves residue on skin and bedding. Second — and distinctively — MIT is used in water-based wall paint, and freshly painted rooms have caused airborne allergic contact dermatitis in sensitized people, with reactions to the air itself rather than to touching anything. A newly painted bedroom is a documented trigger.
Is methylisothiazolinone toxic?
Not in the cancer or systemic-poison sense — the concern is allergy. MIT is a potent skin sensitizer, meaning it can train the immune system to react to it. Once someone is sensitized, even tiny amounts cause allergic contact dermatitis: itching, rash and, in airborne cases, facial and eyelid involvement. For people who are not sensitized, MIT at today's regulated levels is low-concern; for the sensitized minority, it is a real and sometimes severe problem.
How do I avoid it?
Check labels for "methylisothiazolinone" or "methylchloroisothiazolinone" on shampoos, washes and wet wipes, since EU rules now ban MIT from leave-on cosmetics and limit it in rinse-off products. For the bedroom, the high-value step if you or a family member reacts to fresh paint is to choose a low-biocide or isothiazolinone-free water-based paint and to ventilate well while a newly painted room cures. If reactions appear after painting, MIT in the paint is a prime suspect.
Related compounds
Embr is a sleep environment company researching and addressing the chemistry of the bedroom. Research and product development in progress.
Last reviewed 2026-06-27. If you find a factual error, contact us.